Dustin R. Wakeman, PhD
Adjunct Assistant Professor, Dept. of Psychiatry, School of Medicine
Research & Publications
Biography
Selected Publications
- Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's diseaseWakeman DR, Weed MR, Perez SE, Cline EN, Viola KL, Wilcox KC, Moddrelle DS, Nisbett EZ, Kurian AM, Bell AF, Pike R, Jacobson PB, Klein WL, Mufson EJ, Lawrence MS, Elsworth JD. Intrathecal amyloid‐beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease. Neuropathology And Applied Neurobiology 2022, 48: e12800. PMID: 35156715, PMCID: PMC10902791, DOI: 10.1111/nan.12800.
- The Future of GDNF in Parkinson's DiseaseManfredsson F, Polinski N, Subramanian T, Boulis N, Wakeman D, Mandel R. The Future of GDNF in Parkinson's Disease. Frontiers In Aging Neuroscience 2020, 12: 593572. PMID: 33364933, PMCID: PMC7750181, DOI: 10.3389/fnagi.2020.593572.
- Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migrationLee J, Zhang R, Yan M, Duggineni S, Wakeman D, Niles W, Feng Y, Chen J, Hamblin M, Han E, Gonzalez R, Fang X, Zhu Y, Wang J, Xu Y, Wenger D, Seyfried T, An J, Sidman R, Huang Z, Snyder E. Chemical mutagenesis of a GPCR ligand: Detoxifying “inflammo-attraction” to direct therapeutic stem cell migration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 31177-31188. PMID: 33219123, PMCID: PMC7733796, DOI: 10.1073/pnas.1911444117.
- Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivoHiller B, Marmion D, Gross R, Thompson C, Chavez C, Brundin P, Wakeman D, McMahon C, Kordower J. Mitomycin-C treatment during differentiation of induced pluripotent stem cell-derived dopamine neurons reduces proliferation without compromising survival or function in vivo. Stem Cells Translational Medicine 2020, 10: 278-290. PMID: 32997443, PMCID: PMC7848297, DOI: 10.1002/sctm.20-0014.
- A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral InjuryHartman R, Nathan N, Ghosh N, Pernia C, Law J, Nuryyev R, Plaia A, Yusof A, Tone B, Dulcich M, Wakeman D, Dilmac N, Niles W, Sidman R, Obenaus A, Snyder E, Ashwal S. A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury. Cell Reports 2020, 31: 107622. PMID: 32402283, DOI: 10.1016/j.celrep.2020.107622.
- Cell Replacement Strategies for Parkinson’s DiseaseChatterjee D, Wakeman D, Kordower J. Cell Replacement Strategies for Parkinson’s Disease. 2017, 73-83. DOI: 10.1007/978-3-319-57153-9_4.
- Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In VivoWakeman D, Hiller B, Marmion D, McMahon C, Corbett G, Mangan K, Ma J, Little L, Xie Z, Perez-Rosello T, Guzman J, Surmeier D, Kordower J. Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo. Stem Cell Reports 2017, 9: 149-161. PMID: 28579395, PMCID: PMC5511045, DOI: 10.1016/j.stemcr.2017.04.033.
- Autologous iPSC‐derived dopamine neuron grafts show considerable promise in a nonhuman primate model of Parkinson's diseaseWakeman D. Autologous iPSC‐derived dopamine neuron grafts show considerable promise in a nonhuman primate model of Parkinson's disease. Movement Disorders 2015, 30: 1034-1034. PMID: 26095814, DOI: 10.1002/mds.26267.
- Survival and Integration of Neurons Derived from Human Embryonic Stem Cells in MPTP-Lesioned PrimatesWakeman DR, Weiss S, Sladek JR, Elsworth JD, Bauereis B, Leranth C, Hurley PJ, Roth RH, Redmond DE. Survival and Integration of Neurons Derived from Human Embryonic Stem Cells in MPTP-Lesioned Primates. Cell Transplantation 2014, 23: 981-994. PMID: 23562290, DOI: 10.3727/096368913x664865.
- Peripheral alpha‐synuclein and Parkinson's diseaseOlanow C, Wakeman D, Kordower J. Peripheral alpha‐synuclein and Parkinson's disease. Movement Disorders 2014, 29: 963-966. PMID: 25043799, DOI: 10.1002/mds.25966.
- Special issue on stem cellsWakeman D, Kordower J. Special issue on stem cells. The Journal Of Comparative Neurology 2014, 522: 2689-2690. PMID: 24942075, DOI: 10.1002/cne.23611.
- Neonatal immune-tolerance in mice does not prevent xenograft rejectionMattis V, Wakeman D, Tom C, Dodiya H, Yeung S, Tran A, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, Thompson L, Kordower J, Svendsen C. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Experimental Neurology 2014, 254: 90-98. PMID: 24440640, PMCID: PMC3954854, DOI: 10.1016/j.expneurol.2014.01.007.
- Homing of Neural Stem Cells From the Venous Compartment Into a Brain Infarct Does Not Involve Conventional Interactions With Vascular EndotheliumGoncharova V, Das S, Niles W, Schraufstatter I, Wong A, Povaly T, Wakeman D, Miller L, Snyder E, Khaldoyanidi S. Homing of Neural Stem Cells From the Venous Compartment Into a Brain Infarct Does Not Involve Conventional Interactions With Vascular Endothelium. Stem Cells Translational Medicine 2014, 3: 229-240. PMID: 24396034, PMCID: PMC3925049, DOI: 10.5966/sctm.2013-0052.
- Growth Dynamics of Fetal Human Neural Stem CellsNiles W, Wakeman D, Snyder E. Growth Dynamics of Fetal Human Neural Stem Cells. 2013, 75-89. DOI: 10.1007/978-1-4614-7696-2_5.
- Functional Multipotency of Stem Cells: A Conceptual Review of Neurotrophic Factor-Based Evidence and Its Role in Translational ResearchD Y, Yu, Dou, Ropper, E A, Li, Jianxue, Kabatas, Serdar, Wakeman, R D, Wang, Junmei, Sullivan, P M, Redmond Jr., Eugene D, Langer, Robert, Snyder, Y E, Sidman, L R. Functional Multipotency of Stem Cells: A Conceptual Review of Neurotrophic Factor-Based Evidence and Its Role in Translational Research. Current Neuropharmacology 2011, 9: 574-585. PMID: 22654717, PMCID: PMC3263453, DOI: 10.2174/157015911798376299.
- Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s diseaseKriks S, Shim J, Piao J, Ganat Y, Wakeman D, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal M, Surmeier D, Kordower J, Tabar V, Studer L. Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature 2011, 480: 547-551. PMID: 22056989, PMCID: PMC3245796, DOI: 10.1038/nature10648.
- Cell Transplantation and Gene Therapy in Parkinson's DiseaseWakeman D, Dodiya H, Kordower J. Cell Transplantation and Gene Therapy in Parkinson's Disease. Annals Of Global Health 2011, 78: 126-158. PMID: 21259269, DOI: 10.1002/msj.20233.
- Microarray-based Transcriptional and Epigenetic Profiling of Matrix Metalloproteinases, Collagens, and Related Genes in Cancer*Chernov A, Baranovskaya S, Golubkov V, Wakeman D, Snyder E, Williams R, Strongin A. Microarray-based Transcriptional and Epigenetic Profiling of Matrix Metalloproteinases, Collagens, and Related Genes in Cancer*. Journal Of Biological Chemistry 2010, 285: 19647-19659. PMID: 20404328, PMCID: PMC2885243, DOI: 10.1074/jbc.m109.088153.
- Cellular Repair in the Parkinsonian Nonhuman Primate BrainRedmond DE, Weiss S, Elsworth JD, Roth RH, Wakeman DR, Bjugstad KB, Collier TJ, Blanchard BC, Teng YD, Synder EY, Sladek JR. Cellular Repair in the Parkinsonian Nonhuman Primate Brain. Rejuvenation Research 2010, 13: 188-194. PMID: 20370501, PMCID: PMC2946058, DOI: 10.1089/rej.2009.0960.
- Functional Multipotency of Neural Stem Cells and Its Therapeutic ImplicationsTeng Y, Kabatas S, Li J, Wakeman D, Snyder E, Sidman R. Functional Multipotency of Neural Stem Cells and Its Therapeutic Implications. 2009, 255-270. DOI: 10.1007/978-90-481-3375-8_16.
- Culture System for Rodent and Human Oligodendrocyte Specification, Lineage Progression, and MaturationEspinosa‐Jeffrey A, Wakeman D, Kim S, Snyder E, de Vellis J. Culture System for Rodent and Human Oligodendrocyte Specification, Lineage Progression, and Maturation. Current Protocols In Stem Cell Biology 2009, 10: 2d.4.1-2d.4.26. PMID: 19725014, DOI: 10.1002/9780470151808.sc02d04s10.
- Long‐Term Multilayer Adherent Network (MAN) Expansion, Maintenance, and Characterization, Chemical and Genetic Manipulation, and Transplantation of Human Fetal Forebrain Neural Stem CellsWakeman DR, Hofmann MR, Redmond DE, Teng YD, Snyder EY. Long‐Term Multilayer Adherent Network (MAN) Expansion, Maintenance, and Characterization, Chemical and Genetic Manipulation, and Transplantation of Human Fetal Forebrain Neural Stem Cells. Current Protocols In Stem Cell Biology 2009, 9: 2d.3.1-2d.3.77. PMID: 19455542, DOI: 10.1002/9780470151808.sc02d03s9.
- Neural ProgenitorsWakeman D, Hofmann M, Teng Y, Snyder E. Neural Progenitors. 2009, 7: 1-44. DOI: 10.1007/978-90-481-2269-1_1.
- Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cellsRedmond DE, Bjugstad KB, Teng YD, Ourednik V, Ourednik J, Wakeman DR, Parsons XH, Gonzalez R, Blanchard BC, Kim SU, Gu Z, Lipton SA, Markakis EA, Roth RH, Elsworth JD, Sladek JR, Sidman RL, Snyder EY. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 12175-12180. PMID: 17586681, PMCID: PMC1896134, DOI: 10.1073/pnas.0704091104.
- Adhesive Interactions Between Human Neural Stem Cells and Inflamed Human Vascular Endothelium Are Mediated by IntegrinsMueller F, Serobyan N, Schraufstatter I, DiScipio R, Wakeman D, Loring J, Snyder E, Khaldoyanidi S. Adhesive Interactions Between Human Neural Stem Cells and Inflamed Human Vascular Endothelium Are Mediated by Integrins. Stem Cells 2006, 24: 2367-2372. PMID: 17071855, PMCID: PMC2885956, DOI: 10.1634/stemcells.2005-0568.
- Large animal models are critical for rationally advancing regenerative therapiesWakeman D, Crain A, Snyder E. Large animal models are critical for rationally advancing regenerative therapies. Regenerative Medicine 2006, 1: 405-413. PMID: 17465832, PMCID: PMC2905042, DOI: 10.2217/17460751.1.4.405.
- Genome wide expression analysis of human neural stem cells in vitroWakeman D, Snyder E, Redmond D, Loring J, Mueller F. Genome wide expression analysis of human neural stem cells in vitro. Experimental Neurology 2006, 198: 593. DOI: 10.1016/j.expneurol.2006.02.102.