Gary Altwerger, MD
Assistant Professor of Obstetrics and Gynecology; Head of Gynecologic Oncology Morbidity and Mortality , Obstetrics, Gynecology & Reproductive Sciences; Institutional Review Board Committee Member, Gynecologic Oncology
Research & Publications
Biography
News
Locations
Research Summary
Developing minimally invasive surgical techniques in gynecologic oncology:
- Video: Novel laparoscopic anterior pancreatic peritonectomy for splenectomy in recurrent ovarian cancer: https://pubmed.ncbi.nlm.nih.gov/38724238/
- Video: Laparoscopic resection of interaortocaval mass in recurrent ovarian cancer: https://pubmed.ncbi.nlm.nih.gov/38719278/
Understanding carboplatin hypersensitivity risk factors, elucidating its cause and determining desensitization efficacy for hypersensitive patients:
Disrupting tumor DNA repair pathways for chemotherapy-resistant gynecologic cancers:
https://pubmed.ncbi.nlm.nih.gov/38029867/
Identifying and using novel targets like folic acid receptor for the treatment of biologically aggressive uterine cancer:
https://pubmed.ncbi.nlm.nih.gov/29440294/
Use of medical cannabis for pain and peripheral neuropathy in patients with gynecologic cancer:
https://pubmed.ncbi.nlm.nih.gov/33204797/
Coauthors
Research Interests
Drug Hypersensitivity; DNA Mismatch Repair; Lynch Syndrome II; Hereditary Breast and Ovarian Cancer Syndrome
Selected Publications
- Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repairAltwerger G, Ghazarian M, Glazer P. Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair. Seminars In Cancer Biology 2023, 98: 11-18. PMID: 38029867, PMCID: PMC10872265, DOI: 10.1016/j.semcancer.2023.11.007.
- Prescribed medical cannabis in women with gynecologic malignancies: A single-institution survey-based studyWebster EM, Yadav GS, Gysler S, McNamara B, Black J, Tymon-Rosario J, Zeybek B, Han C, Arkfeld CK, Andikyan V, Menderes G, Huang G, Azodi M, Silasi DA, Santin AD, Schwartz PE, Ratner ES, Altwerger G. Prescribed medical cannabis in women with gynecologic malignancies: A single-institution survey-based study. Gynecologic Oncology Reports 2020, 34: 100667. PMID: 33204797, PMCID: PMC7653050, DOI: 10.1016/j.gore.2020.100667.
- In vitro and in vivo activity of IMGN853, an Antibody-Drug Conjugate targeting Folate Receptor Alpha linked to DM4, in biologically aggressive endometrial cancersAltwerger G, Bonazzoli E, Bellone S, Egawa-Takata T, Menderes G, Pettinella F, Bianchi A, Riccio F, Feinberg J, Zammataro L, Han C, Yadav G, Dugan K, Morneault A, Ponte JF, Buza N, Hui P, Wong S, Litkouhi B, Ratner E, Silasi DA, Huang GS, Azodi M, Schwartz PE, Santin AD. In vitro and in vivo activity of IMGN853, an Antibody-Drug Conjugate targeting Folate Receptor Alpha linked to DM4, in biologically aggressive endometrial cancers. Molecular Cancer Therapeutics 2018, 17: molcanther.0930.2017. PMID: 29440294, PMCID: PMC5932245, DOI: 10.1158/1535-7163.mct-17-0930.
- Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancerAltwerger G, Florsheim EB, Menderes G, Black J, Schwab C, Gressel GM, Nelson WK, Carusillo N, Passante T, Huang G, Litkouhi B, Azodi M, Silasi DA, Santin A, Schwartz PE, Ratner ES. Impact of carboplatin hypersensitivity and desensitization on patients with recurrent ovarian cancer. Journal Of Cancer Research And Clinical Oncology 2018, 144: 2449-2456. PMID: 30255380, DOI: 10.1007/s00432-018-2753-y.
- Platinum desensitization in patients with carboplatin hypersensitivity: A single-institution retrospective studyAltwerger G, Gressel GM, English DP, Nelson WK, Carusillo N, Silasi DA, Azodi M, Santin A, Schwartz PE, Ratner ES. Platinum desensitization in patients with carboplatin hypersensitivity: A single-institution retrospective study. Gynecologic Oncology 2016, 144: 77-82. PMID: 27789084, DOI: 10.1016/j.ygyno.2016.09.027.
- Conventional laparoscopic resection of platinum-sensitive recurrent oligometastatic ovarian cancer lesion in the interaortocaval region.Abozenah Y, Vlamis C, Ghazarian M, Harold J, Tymon-Rosario J, Altwerger G. Conventional laparoscopic resection of platinum-sensitive recurrent oligometastatic ovarian cancer lesion in the interaortocaval region. Int J Gynecol Cancer 2024 PMID: 38719278, DOI: 10.1136/ijgc-2024-005269.
- Laparoscopic pancreatic peritonectomy with splenectomy for recurrent ovarian cancer: a novel approach to achieve R0 while preserving the pancreatic body and tail.Vlamis C, Abozenah Y, Pebley N, Chang YE, McNamara B, Altwerger G. Laparoscopic pancreatic peritonectomy with splenectomy for recurrent ovarian cancer: a novel approach to achieve R0 while preserving the pancreatic body and tail. Int J Gynecol Cancer 2024 PMID: 38724238, DOI: 10.1136/ijgc-2024-005358.
- Surgical and oncologic outcomes in surgically treated women 80 years and older with endometrioid endometrial cancer as a function of their comorbiditiesAlAshqar A, Ghazarian M, Webster E, Upadhyay A, Azodi M, Schwartz P, Ratner E, Altwerger G. Surgical and oncologic outcomes in surgically treated women 80 years and older with endometrioid endometrial cancer as a function of their comorbidities. Gynecologic Oncology Reports 2023, 49: 101240. PMID: 37636496, PMCID: PMC10450407, DOI: 10.1016/j.gore.2023.101240.
- Real-World Efficacy and Safety of PARP Inhibitors in Recurrent Ovarian Cancer Patients With Somatic BRCA and Other Homologous Recombination Gene MutationsPan Y, Hood A, Ahmad H, Altwerger G. Real-World Efficacy and Safety of PARP Inhibitors in Recurrent Ovarian Cancer Patients With Somatic BRCA and Other Homologous Recombination Gene Mutations. Annals Of Pharmacotherapy 2023, 57: 1162-1171. PMID: 36651235, PMCID: PMC11062080, DOI: 10.1177/10600280221149136.