Rummana Aslam, MBBS
Research & Publications
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Research Summary
Current research projects
A. Digitalization of the Physical Performance Test and Training
The digitalized version of the Physical Performance Test, measures the movements of the human body with the help of sensors. The two types of sensors used for these measurements are the Inertial Measurement Unit (IMU) and force sensors. Digitizing the conventional test will be used to obtain objective and continuous data from patients undergoing acute rehabilitation and compare to conventional methods. The goal is to increase the accuracy of the assessment of physical performance Computer software will be developed to evaluate the test score of the patient.
B. Rehabilitation Device for and Mirror Therapy
The primary objective of this study is to compare the MiraTT hand therapy device mirror therapy to conventional mirror therapy. In conventional mirror therapy the affected hand does not actually. In MiraTT mirror therapy the digits of the affected hand actually move and mirror the movement of the digits of the normal hand
C. The Automated Test of Embodied Cognition (ATEC) uses motion capture technology and machine learning algorithms to assess cognition in action. Unlike conventional neuropsychological assessments that rely on paper and pencil and computer tasks to measure attention, memory, and executive function, ATEC captures those abilities using cognitively demanding physical tasks. Measuring cognition in action is a paradigm shift, in keeping with contemporary neuroscience, and is especially relevant for population with cognitive disordersThe aims are: 1) Algorithm development for scoring, following procedures proven effective in our prototype. Data will include motion capture data that hasalready been collected or is being collected in 2 current VA clinical trials and motion capture data from participants with specific cognitive disorders to be recruited in this proposed study. These include patients with mild to moderate cases of Stroke, Dementia (all cause), mild TBI, Movement Disorders and chronic Alcohol Use Disorder. 2) Improvements in user interface of the computer application along with adaptations for VA Telehealth. This will involve improving the user interface, embedding the scoring algorithms into the interface, redoing some of the video instructions, and developing, and then qualitatively assessing, the Telehealthversion. 3) Develop report templates with scores, interpretation, and treatment recommendations in a version suitable for clinicians and a version for patients and caregivers.The deliverables at the end of 3 years include 1) an easily transferable technology (computer application) that provides an automated high-fidelity administration of ATEC and automated scoring of patient performance.2) Test reports with easily readable graphics and interpretation of findings that are automatically produced. 3) A Telehealth version specific to the VA National TeleNeurology Program (NTNP).
D. Botulinum Toxin-A for Hidradenitis Suppurativa. Randomized double blinded clinical trial
The primary objective of this Phase IV study is to determine if Botulinum Toxin-A induces regression, remission, or relapse of hidradenitis suppurativa lesions.
The secondary objective of this investigation is to determine if Botulinum Toxin-A improves patient-reported quality of life outcomes in hidradenitis suppurativa
E . Effect of the Duration of Hyperbaric Oxygen Treatment on Femoral Head Avascular Necrosis
Primary Objective
The primary objective of this study is to determine whether the length of hyperbaric oxygen therapy treatment sessions (3 weeks versus 6 weeks), combined with core decompression with autologous bone marrow aspirate concentrate effect the incidence of femoral head collapse of patients with femoral head avascular necrosis.
Secondary Objective
The secondary objective of this study is to determine whether the length of hyperbaric oxygen therapy treatment sessions affect patient pain and function in patients with femoral head avascular necrosis.
Extensive Research Description
My research interest focuses on the following areas
1. Wound repair and regeneration
2. New innovative applications of hyperbaric oxygen therapy
3. Quantification of physical performance and cognition
Research Interests
Patient Outcome Assessment; Analytical, Diagnostic and Therapeutic Techniques and Equipment
Public Health Interests
Clinical Trials
Selected Publications
- WHS guidelines for the treatment of pressure ulcers—2023 updateGould L, Alderden J, Aslam R, Barbul A, Bogie K, Masry M, Graves L, White‐Chu E, Ahmed A, Boanca K, Brash J, Brooks K, Cockron W, Kennerly S, Livingston A, Page J, Stephens C, West V, Yap T. WHS guidelines for the treatment of pressure ulcers—2023 update. Wound Repair And Regeneration 2023, 32: 6-33. PMID: 37970711, DOI: 10.1111/wrr.13130.
- WHS Guidelines for the Treatment of Pressure Ulcers – 2023 updateWRR
- Role of quercetin and rutin in enhancing the therapeutic potential of mesenchymal stem cells for cold induced burn woundIrfan F, Jameel F, Khan I, Aslam R, Faizi S, Salim A. Role of quercetin and rutin in enhancing the therapeutic potential of mesenchymal stem cells for cold induced burn wound. Regenerative Therapy 2022, 21: 225-238. PMID: 36092499, PMCID: PMC9420879, DOI: 10.1016/j.reth.2022.07.011.
- Chronic Venous Stasis UlcerHenry Derbes MD, Rummana Aslam, MD. Best Wound Practice (a single site of peer-reviewed, step-by-step examples of best treatment of most wounds) https://bestwoundpractice.com/chronic-venous-stasis-ulcer/
- Pyoderma GangrenosumAli Najam MD, Rummana Aslam MD, Henry Derbes MD. Best Wound Practice (a single site of peer-reviewed, step-by-step examples of best treatment of most wounds) https://bestwoundpractice.com/pyoderma-gangrenosum-2/
- Role of quercetin and rutin in enhancing the therapeutic potential of mesenchymal stem cells for cold induced burn woundFatima Ifan, Fatima Jameel, Irfan Khan, Rummana Aslam, Shaheen Faizi, Asmat Salim. Regenerative Therapy.Volume 21.Pages 225-238
- Wound healing society 2015 update on guidelines for pressure ulcersGould L, Stuntz M, Giovannelli M, Ahmad A, Aslam R, Mullen-Fortino M, Whitney JD, Calhoun J, Kirsner RS, Gordillo GM. Wound healing society 2015 update on guidelines for pressure ulcers. Wound Repair And Regeneration 2016, 24: 145-162. PMID: 26683529, DOI: 10.1111/wrr.12396.
- Preventing, Minimizing and Managing Pain in Patients with Chronic Wounds: Challenges and Solutions.Thomas E. Serena MD, Saima Aslam, Raphael A. Yaakov MS1, Rummana Aslam MD. Chronic Wound Care Management and Research an international, peer reviewed, open access online journal
- Poster 282 Rehabilitation of the Patient With Chronic Wounds: A Case ReportAslam R, Barbul A, Brown M, Praniewicz S. Poster 282 Rehabilitation of the Patient With Chronic Wounds: A Case Report. PM&R 2011, 3: s269-s269. DOI: 10.1016/j.pmrj.2011.08.309.
- 061Lactate, Oxygen, and Wound HealingAslam R, Scheuenstuhl H, Hopf H, Beckert S, Hussain Z, Hunt T. 061Lactate, Oxygen, and Wound Healing. Wound Repair And Regeneration 2008, 13: a4-a27. DOI: 10.1111/j.1067-1927.2005.130215bi.x.
- 104Hyperbaric oxygen enhances wound lactate production in ratsBeckert S, Aslam R, Farrahi F, Scheuenstuhl H, Hopf H, Königsrainer A, Hunt T. 104Hyperbaric oxygen enhances wound lactate production in rats. Wound Repair And Regeneration 2008, 13: a28-a48. DOI: 10.1111/j.1067-1927.2005.130216h.x.
- Guidelines for the prevention of venous ulcersRobson MC, Cooper DM, Aslam R, Gould LJ, Harding KG, Margolis DJ, Ochs DE, Serena TE, Snyder RJ, Steed DL, Thomas DR, Wiersema‐Bryant L. Guidelines for the prevention of venous ulcers. Wound Repair And Regeneration 2008, 16: 147-150. PMID: 18318800, DOI: 10.1111/j.1524-475x.2008.00355.x.
- Lactate, with Oxygen, Incites AngiogenesisHunt TK, Aslam R, Hussain Z, Beckert S. Lactate, with Oxygen, Incites Angiogenesis. 2008, 614: 73-80. PMID: 18290316, DOI: 10.1007/978-0-387-74911-2_9.
- Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox MechanismsHunt TK, Aslam RS, Beckert S, Wagner S, Ghani QP, Hussain MZ, Roy S, Sen CK. Aerobically Derived Lactate Stimulates Revascularization and Tissue Repair via Redox Mechanisms. Antioxidants & Redox Signaling 2007, 9: 1115-1124. PMID: 17567242, PMCID: PMC2443402, DOI: 10.1089/ars.2007.1674.
- Guidelines for the treatment of arterial insufficiency ulcersHopf HW, Ueno C, Aslam R, Burnand K, Fife C, Grant L, Holloway A, Iafrati MD, Mani R, Misare B, Rosen N, Shapshak D, Slade J, West J, Barbul A. Guidelines for the treatment of arterial insufficiency ulcers. Wound Repair And Regeneration 2006, 14: 693-710. PMID: 17199834, DOI: 10.1111/j.1524-475x.2006.00177.x.
- Guidelines for the treatment of venous ulcersRobson MC, Cooper DM, Aslam R, Gould LJ, Harding KG, Margolis DJ, Ochs DE, Serena TE, Snyder RJ, Steed DL, Thomas DR, Wiersma‐Bryant L. Guidelines for the treatment of venous ulcers. Wound Repair And Regeneration 2006, 14: 649-662. PMID: 17199831, DOI: 10.1111/j.1524-475x.2006.00174.x.
- Guidelines for the treatment of pressure ulcersWhitney J, Phillips L, Aslam R, Barbul A, Gottrup F, Gould L, Robson MC, Rodeheaver G, Thomas D, Stotts N. Guidelines for the treatment of pressure ulcers. Wound Repair And Regeneration 2006, 14: 663-679. PMID: 17199832, DOI: 10.1111/j.1524-475x.2006.00175.x.
- Downregulation of poly(ADP-ribosyl)ation is involved in HIF-1 alpha mediated stimulation of VEGF expression by IGF-IBeckert S, Farrahi F, Aslam R, Scheuenstuhl H, Königsrainer A, Hussain Z, Hunt T. Downregulation of poly(ADP-ribosyl)ation is involved in HIF-1 alpha mediated stimulation of VEGF expression by IGF-I. Journal Of The American College Of Surgeons 2005, 201: s62-s63. DOI: 10.1016/j.jamcollsurg.2005.06.140.
- High lactate in wounds may initiate vasculogenesis via stem cell homingAslam R, Beckert S, Scheuenstuhl H, Hussain Z, Hunt T. High lactate in wounds may initiate vasculogenesis via stem cell homing. Journal Of The American College Of Surgeons 2005, 201: s58. DOI: 10.1016/j.jamcollsurg.2005.06.128.
- Laktat stimuliert die Migration von humanen EndothelzellenBeckert S, Coerper S, Aslam R, Scheuenstuhl H, Königsrainer A, Hussain M. Laktat stimuliert die Migration von humanen Endothelzellen. 2005, 34: 359-360. DOI: 10.1007/3-540-26560-0_128.
- 049Lactate Controls Vascular Development in Wound HealingAslam R, Scheuenstuhl H, Beckert S, Hopf H, Hussain Z, Hunt T. 049Lactate Controls Vascular Development in Wound Healing. Wound Repair And Regeneration 2004, 12: a14-a14. DOI: 10.1111/j.1067-1927.2004.0abstractav.x.
- 031IGF‐I stimulates VEGF production in endothelial cells by inhibiting poly(ADP‐Ribose)‐polymeraseBeckert S, Scheuenstuhl H, Farrahi F, Aslam R, Hunt T, Hussain Z. 031IGF‐I stimulates VEGF production in endothelial cells by inhibiting poly(ADP‐Ribose)‐polymerase. Wound Repair And Regeneration 2004, 12: a10-a10. DOI: 10.1111/j.1067-1927.2004.0abstractad.x.